Protein Details: Transient receptor potential cation channel subfamily V member 3

Protein ID

ICDB_Pro_1287

Protein Name

Transient receptor potential cation channel subfamily V member 3

Gene Name

TRPV3

Organism

Homo sapiens (Human)

Length

790 amino acids

AlphaFoldDB

AF-Q8NET8-F1-model_v4.pdb

Function

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen)

Sequence

MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV

PDB Structures

6H9J 6HA6 6MHO 6MHS 6MHV 6MHW 6MHX 6OT2 6OT5 6UW4 6UW6 6UW8 6UW9 7QQN 7XJ0 7XJ1 7XJ2 7XJ3 8GKA 8GKG

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/nature00894; 10.1038/nature00882; 10.1038/jid.2011.122; 10.1038/jid.2014.429; 10.1016/j.ajhg.2012.02.006; 10.1111/j.1365-2133.2012.11115.x

RefSeq

NP_659505.1 [Q8NET8-1]